Surgical management of aortic root disease in Marfan: a systematic review and meta analysis Jan 2011
Heart doi:10.1136/hrt.2010.210286
Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysis
Umberto Benedetto1, Giovanni Melina1, Johanna J M Takkenberg2, Antonino Roscitano1, Emiliano Angeloni1, Riccardo Sinatra1
Abstract
Context Surgical treatment of aortic root aneurysm in Marfan syndrome (MFS) patients.
Objective To compare results of total root replacement versus valve-sparing aortic root replacement in MFS patients.
Data Sources PubMed, Embase and Cochrane library were searched from January 1966 until February 2010 looking for papers reporting on aortic root operations in MFS patients. 530 studies were retrieved.
Study Selection Finally, 11 publications were enrolled. Inclusion criteria were observational studies reporting valve-related morbidity and mortality after total root replacement (TTR) and/or valve-sparing root replacement (VSRR) in patients with MFS and study size n330, reflecting the centre's experience.
Data Extraction Data obtained from papers reporting both TRR and VSRR cohorts were analysed separately. In case of multiple publications, the most recent and complete report was selected. If the total number of patient-years was not provided, we calculated it by multiplying the number of hospital survivors with the mean follow-up duration of that study.
Results Overall, 1385 patients were analysed (972 patients had TTR and 413 patients had VSRR). Reintervention rate was 0.3%/year (95% CI 0.1 to 0.5) versus 1.3%/year (95% CI 0.3 to 2.2) (p¼0.02) andthromboembolic events rate was 0.7%/year (95% CI 0.5 to 0.9) versus 0.3%/year (95% CI 0.1 to 0.6) (p¼0.01) after TRR and VSRR, respectively. When composite valve-related events were compared, no difference existed between the two surgical strategies (p¼0.41). Among patients undergoing VSRR, reimplantation was associated with a reduced rate of reintervention compared with remodelling (0.7%/year vs 2.4%/year, p¼0.02).
Conclusions VSRR may represent a valuable option for patients with MFS with aortic aneurysm. However, this technique should be used with caution in patients with valve characteristics at risk for decreased durability.
+ Author Affiliations
1Department of Cardiac Surgery, University of Rome Sapienza, Policlinico S Andrea, Rome, Italy
2Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
- Correspondence to Umberto Benedetto, Cardiac Surgery Department, II School of Medicine, University of Rome “La Sapienza” Via di Grottarossa 1035, Rome, Italy; u2benedetto@libero.it
- Accepted 30 November 2010
- Published Online First 12 January 2011
Link to article abstract and to purchase article: http://heart.bmj.com/content/early/2011/01/11/hrt.2010.210286.abstract