Research News & Publications:
(Click on the titles below. The abstract for each publication will open via PubMed)

2022 Comparative Risks of Initial Aortic Events Associated with Genetic Thoracic Aortic Disease.

2022 Expanding ACTA2 genotypes with corresponding phenotypes overlapping with smooth muscle dysfunction syndrome.

2022 Spontaneous coronary artery dissection is infrequent in individuals with heritable thoracic aortic disease despite partially shared genetic susceptibility.

2021 Marfan syndrome.

2022 Expanding ACTA2 genotypes with corresponding phenotypes overlapping with smooth muscle dysfunction syndrome.

2020 Decrease in surgical case volume of Type A Aortic Dissection during the COVID-19 pandemic raises public health concern

2020 Cerebrovascular Disease Progression in Patients With ACTA2 Arg179 Pathogenic Variants

2019 Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial

2019 Sleep disordered breathing in Marfan syndrome: Value of standard screening questionnaires.

2019 FBN1 Coding Variants and Nonsyndromic Aortic Disease.

2019 MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants.

2019 The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln).

2019 SMAD3 pathogenic variants: risk for thoracic aortic disease and associated complications from the Montalcino Aortic Consortium.

2018 Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations.

2018 Executive function and quality of life in individuals with Marfan syndrome

2017 Mild aerobic exercise blocks elastin fiber fragmentation and aortic dilatation in a mouse model of Marfan syndrome associated aortic aneurysm

2016 International Registry of Patients Carrying TGFBR1 or TGFBR2 Mutations: Results of the Montalcino Aortic Consortium

2016 FOXE3 mutations predispose to thoracic aortic aneurysms and dissections

2016 LOX Mutations Predispose to Thoracic Aortic Aneurysms and Dissections 

2016 The Expanding Clinical Spectrum of Extracardiovascular and Cardiovascular Manifestations of Heritable Thoracic Aortic Aneurysm and Dissection

2016 Multidisciplinary Aortopathy Clinics Should Now Be the Standard of Care in Canada

2015 Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations

2015 MAT2A mutations predispose individuals to thoracic aortic aneurysms

2015 A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome

2014 Familial thoracic aortic aneurysms

2014 Canadian Cardiovascular Society Position Statement on the Management of Thoracic Aortic Disease

2014 Loeys–Dietz syndrome: a primer for diagnosis and management

2014 November 19 Losartan vs Atenolol Study Results: Equal Therapies

2013 CMA International Scientific Meeting

11 Sep 2011: Study Reveals Risk Factor Doubling Chance of Developing Silent Killer

2011 CMA Research Grant Recipient - September 23, 2011

April 2011: Noncanonical TGFB Signaling Contributes to Aortic Aneurysm Progression in Marfan Mice

April 2011: Frightening Risk of Marfan syndrome, and Potential Treatment, Elucidated

Surgical management of aortic root disease in Marfan: a systematic review and meta analysis Jan 2011

Revised Diagnostic Criteria for Marfan syndrome Published in Journal of Medical Genetics Jul 2010

UK Researcher Seeks Couples

BC Children's Hospital Losartan vs. Atenolol Trial is Beginning

Breakthrough in Marfan Research

Update on the Clinical Trial Comparing Atenolol and Losartan